The dynamic microbiome of bone marrow transplantation patients

Date of Event

Department of Biomedical Informatics

Presents
GRAND ROUNDS

Guest Speaker: Joao Xavier, PhD Associate Faculty Member, Computational & Systems Biology Memorial Sloan Kettering Cancer Center

Topic:  The dynamic microbiome of bone marrow transplantation patients
When: Wednesday, September 26, 2018
Time: 3:00 – 4:00PM
Where: *change of venue * Biomedical Informatics conference room L3-045

Abstract:
The gut microbiome protects its human host against invasion by pathogens. Antibiotics, however, can compromise this protection and lead to resistant infections. We study this phenomenon in patients hospitalized to receive bone marrow transplantation, where due to their immune-compromised state the microbiome protection is even more important. This talk will describe lessons learned from analyses of thousands of patients, and the results of a pilot trial to restore microbiome composition with autologous microbiota transplantation

Learning Objectives:
1. Introduce the concept of microbiome colonization resistance
2. Characterize changes in microbiome composition using next-gem sequencing and data analysis
3. Model microbiome dynamics using ecological models
4. Present the results of pilot trial for auto-FMT

Bio:
Joao Xavier is a Cancer Systems Biologist whose goal is to determine mathematical principles governing the behaviors of groups of cells in problems relevant to human health, and to help train the next generation of scientists to tackle Cancer problems from a Systems Biology perspective. As an associate member of MSKCC’s program for Computational and Systems Biology and a 2011 recipient of the NIH New Innovator Award he has worked at the interface of basic science and biomedicine to integrate theoretical analyses and quantitative experiments and determine how collective dynamics emerge from the interactions among individual cells. His group founded in 2010 at Memorial Sloan Kettering Cancer Center applies mathematical models from ecology to cancer biology, to the human microbiome and to the evolution of drug resistance in bacteria.

**CME Credit Available**
The School Of Medicine, State University of New York at Stony Brook, is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The School of Medicine, State University of New York at Stony Brook designates this live activity for a maximum of 1 AMA PRA Category 1 Credit(s) ™.   Physicians should only claim the credit commensurate with the extent of their participation in the activity. Disclosure Policy:  All those in control of CME content are expected to disclose any relevant financial relationship with the provider of commercial products or services discussed in the educational presentation or that have directly supported the CME activity through an educational grant to the sponsoring organization(s).   All commercial relationships that create a conflict with the planners, speakers, author’s control of content must be resolved before the educational activity occurs.

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