Vincent Yang

Vincent Yang headshot

Vincent Yang

SUNY Distinguished Professor
Simons Chair of Medicine
Professor of Medicine, Biomedical Informatics, and Physiology & Biophysics
Renaissance School of Medicine at Stony Brook University

HSC 022
Stony Brook University
Stony Brook, NY 11794
Vincent.Yang@stonybrookmedicine.edu

Biography

Dr. Vincent W. Yang is the Simons Chair of Medicine and Professor of Medicine at the Renaissance School of Medicine at Stony Brook University, with joint appointments in the Departments of Biomedical Informatics and Physiology & Biophysics. A physician scientist and gastroenterologist, he studies the causes and treatment of digestive diseases, particularly inflammatory bowel disease and gastrointestinal cancer.

Dr. Yang earned his PhD at Princeton University and his MD at Rutgers Robert Wood Johnson Medical School. He trained in internal medicine and gastroenterology at Johns Hopkins, where he served on the faculty from 1989 to 2001. He then moved to Emory University School of Medicine as R. Bruce Logue Professor of Medicine and Director of the Division of Digestive Diseases, also directing the NIH-supported Emory Epithelial Pathobiology Research Development Center. He joined Stony Brook in 2011, where, in addition to chairing the Department of Medicine, he is President of Stony Brook Internists and Chief of Service for Medicine at Stony Brook University Hospital.

His laboratory was the first to identify several Krüppel-like transcription factors (KLFs) and has defined their roles in intestinal epithelial biology, stem cells, and cancer. He has led numerous NIH-funded projects and has authored more than 200 articles, reviews, and chapters. He is a member of AOA, ASCI, and the Association of American Physicians, a Fellow of ACP, AGA, and AAAS, and a recipient of the Distinguished Alumnus Award from Rutgers Robert Wood Johnson Medical School. He has served as an editor or editorial board member for journals including Gastroenterology, and on review panels for the NIH, the Veterans Administration, and Taiwan's National Health Research Institutes.

Selected Publications

  1. Kobayashi S, Sullivan C, Bialkowska AB, Saltz JH, Yang VW. Computational immunohistochemical mapping adds immune context to histological phenotypes in mouse models of colitis. Sci Rep. 2023 Sep 1;13(1):14386. doi: 10.1038/s41598-023-41574-8. PMID: 37658187; PMCID: PMC10474139.
  2. Orzechowska-Licari EJ, Bialkowska AB, Yang VW. Sonic Hedgehog and WNT Signaling Regulate a Positive Feedback Loop Between Intestinal Epithelial and Stromal Cells to Promote Epithelial Regeneration. Cell Mol Gastroenterol Hepatol. 2023;16(4):607-642. doi: 10.1016/j.jcmgh.2023.07.004. Epub 2023 Jul 20. PMID: 37481204; PMCID: PMC10470419.
  3. Kobayashi S, Shieh J, Ruiz de Sabando A, Kim J, Liu Y, Zee SY, Prasanna P, Bialkowska AB, Saltz JH, Yang VW. Deep learning-based approach to the characterization and quantification of histopathology in mouse models of colitis. PLoS One. 2022 Aug 29;17(8):e0268954. doi: 10.1371/journal.pone.0268954. PMID: 36037173; PMCID: PMC9423669.
  4. Shieh J, Chu TH, Liu Y, Kim J, Ruiz de Sabando A, Kobayashi S, Zee SY, Sheridan BS, Bialkowska AB, Yang VW. KLF5 protects the intestinal epithelium against Th17 immune response in a murine colitis model. JCI Insight. 2022 Apr 8;7(7):e153488. doi: 10.1172/jci.insight.153488. PMID: 35393949; PMCID: PMC9057631.
  5. Kobayashi S, Saltz JH, Yang VW. State of machine and deep learning in histopathological applications in digestive diseases. World J Gastroenterol. 2021 May 28;27(20):2545-2575. doi: 10.3748/wjg.v27.i20.2545. PMID: 34092975; PMCID: PMC8160628.
  6. Kim CK, Saxena M, Maharjan K, Song JJ, Shroyer KR, Bialkowska AB, Shivdasani RA, Yang VW. Krüppel-like Factor 5 Regulates Stemness, Lineage Specification, and Regeneration of Intestinal Epithelial Stem Cells. Cell Mol Gastroenterol Hepatol. 2020;9(4):587-609. doi: 10.1016/j.jcmgh.2019.11.009. Epub 2019 Nov 25. PMID: 31778829; PMCID: PMC7078555.
  7. Ghaleb AM, Yang VW. Krüppel-like factor 4 (KLF4): What we currently know. Gene. 2017 May 5;611:27-37. doi: 10.1016/j.gene.2017.02.025. Epub 2017 Feb 22. PMID: 28237823; PMCID: PMC5391259.
  8. Bialkowska AB, Yang VW, Mallipattu SK. Krüppel-like factors in mammalian stem cells and development. Development. 2017 Mar 1;144(5):737-754. doi: 10.1242/dev.145441. PMID: 28246209; PMCID: PMC5374354.
  9. McConnell BB, Yang VW. Mammalian Krüppel-like factors in health and diseases. Physiol Rev. 2010 Oct;90(4):1337-81. doi: 10.1152/physrev.00058.2009. PMID: 20959618; PMCID: PMC2975554.
  10. McConnell BB, Ghaleb AM, Nandan MO, Yang VW. The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology. Bioessays. 2007 Jun;29(6):549-57. doi: 10.1002/bies.20581. Erratum in: Bioessays. 2007 Sep;29(9):946. PMID: 17508399; PMCID: PMC2211634.
  11. Zhang W, Chen X, Kato Y, Evans PM, Yuan S, Yang J, Rychahou PG, Yang VW, He X, Evers BM, Liu C. Novel cross talk of Kruppel-like factor 4 and beta-catenin regulates normal intestinal homeostasis and tumor repression. Mol Cell Biol. 2006 Mar;26(6):2055-64. doi: 10.1128/MCB.26.6.2055-2064.2006. PMID: 16507986; PMCID: PMC1430292.
  12. Zhao W, Hisamuddin IM, Nandan MO, Babbin BA, Lamb NE, Yang VW. Identification of Krüppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer. Oncogene. 2004 Jan 15;23(2):395-402. doi: 10.1038/sj.onc.1207067. PMID: 14724568; PMCID: PMC1351029.
  13. Katz JP, Perreault N, Goldstein BG, Lee CS, Labosky PA, Yang VW, Kaestner KH. The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development. 2002 Jun;129(11):2619-28. doi: 10.1242/dev.129.11.2619. PMID: 12015290; PMCID: PMC2225535.
  14. Giardiello FM, Yang VW, Hylind LM, Krush AJ, Petersen GM, Trimbath JD, Piantadosi S, Garrett E, Geiman DE, Hubbard W, Offerhaus GJ, Hamilton SR. Primary chemoprevention of familial adenomatous polyposis with sulindac. N Engl J Med. 2002 Apr 4;346(14):1054-9. doi: 10.1056/NEJMoa012015. PMID: 11932472; PMCID: PMC2225537.
  15. Shields JM, Christy RJ, Yang VW. Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest. J Biol Chem. 1996 Aug 16;271(33):20009-17. doi: 10.1074/jbc.271.33.20009. PMID: 8702718; PMCID: PMC2330254.